49ers Sign WR St. Brown, Release WR Isabella

The following release is courtesy of the San Francisco 49ers

The San Francisco 49ers today announced they have signed WR Equanimeous (eck-wah-nihm-ee-ous) St. Brown to a one-year deal. In order to make room on the roster, the team released WR Andy Isabella.

St. Brown (6-5, 214) was originally drafted by the Green Bay Packers in the sixth round (207th overall) of the 2018 NFL Draft. Throughout his six-year NFL career with the Packers (2018-21), Chicago Bears (2022-23) and New Orleans Saints (2024), he has appeared in 62 games (28 starts) and registered 63 receptions for 928 yards (14.7 average) and two touchdowns.

49ers have signed WR Equanimeous St. Brown to a one-year deal and released WR Andy Isabella.

— Adam Schefter (@AdamSchefter) August 5, 2025

He has also appeared in three postseason contests (one start) with the Packers and recorded two receptions for 37 yards (18.5 average). In 2024, St. Brown spent time on the Saints practice squad and appeared in two games. He then signed with San Francisco on July 22, 2025 and was released by the team on July 31.

A 28-year-old native of Placentia, CA, St. Brown attended the University of Notre Dame for three seasons (2015-17) where he appeared in 32 games (25 starts) and registered 92 receptions for 1,484 yards (16.1 average) and 13 touchdowns.

Isabella (5-9, 188) originally signed to the team on July 31, 2025.

More San Francisco 49ers content from Sactown Sports

“I honestly just came up here to air a grievance,” George Kittle said as he interrupted NFL Network’s interview with fellow San Francisco 49ers teammate Fred Warner.

“Our team got a memo today that smelling salts and ammonia packets were made illegal in the NFL and I’ve been distraught all day,” he continued.

Kittle seemingly broke the news to the NFL world, lightheartedly saying he considered retirement and that they “need to come up with a middle ground.”

San Francisco’s six-time Pro-Bowl tight end is entering his eighth NFL season, and their 2025 preseason debut is set for Saturday against the Denver Broncos.

George Kittle speaks on out NFL’s smelling smalts, ammonia ban

Upcoming San Francisco 49ers Schedule

Preseason

• Saturday, August 9th – vs. Denver Broncos – 5:30 PM PT
• Saturday, August 16th – @ Las Vegas Raiders – 1:00 PM PT
• Saturday, August 23rd – vs. Los Angeles Chargers – 5:30 PM PT

Regular Season

• Sunday, September 7th – @ Seattle Seahawks – 1:05 PM PT  *Season opener*
• Sunday, September 14th – @ New Orleans Saints – 10:00 AM PT
• Sunday, September 21st – vs. Arizona Cardinals – 1:25 PM PT
• Sunday, September 28th – vs. Jacksonville Jaguars – 1:05 PM PT
• Thursday, October 2nd – @ Los Angeles Rams – 5:15 PM PT

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