Matt Barrows on if the 49ers defense can survive the loss of Nick Bosa

The San Francisco 49ers will have to dig deep and search for answers on defense as they navigate the 2025 season without star defensive end Nick Bosa, who suffered a torn ACL during Week 3.

During Monday morning’s edition of The Carmichael Dave Show with Jason Ross, The Athletic’s Matt Barrows joined the show to share his thoughts on the 49ers’ loss to the Jacksonville Jaguars, forecast if this defense can weather the loss of Bosa going forward, and much more.

Plus, Matt and the guys look ahead to this week’s Thursday Night Football matchup against the Los Angeles Rams.

Be sure to listen to and watch the entire interview with Matt Barrows right here or on the Sactown Sports 1140 YouTube page.

Topics Discussed: 49ers, Injury concerns & much more

• Thoughts on the 49ers’ loss to the Jaguars
• How much has the loss of Nick Bosa affected the San Francisco defense?
• “They’ve got one sack master, really good edge rusher on the team right now, and that’s Bryce Huff, but he’s not an every-down guy… You need multiple.”
• Former 49ers DE Arik Armstead came up big for the Jags in crunch time on Sunday
• Thursday’s matchup against the Los Angeles Rams is looming large as a big game for San Francisco
• What transpired at the end of Sunday’s game between DC Robert Saleh and Jags head coach Liam Coen?
• When will George Kittle and Brandon Aiyuk be back on the field for the 49ers?

Listen to The Carmichael Dave Show with Jason Ross from 6 – 10 a.m. PST, Monday through Friday, on Sactown Sports 1140.

Click here for full episodes of The Carmichael Dave Show with Jason Ross.

Check out more 49ers & NFL content from Sactown Sports.

More San Francisco 49ers content from Sactown Sports

Previously unbeaten San Francisco’s loss to Jacksonville on Sunday included a heated exchange after the game between 49ers defensive coordinator Robert Saleh and Jaguars head coach Liam Coen, who had to be separated.

Saleh had raised Coen’s ire on Thursday when he remarked about the Jaguars coaches being adept at “legally” stealing opponents’ signs, which he framed as a compliment. Coen didn’t take it as such and apparently let Saleh know after Jacksonville’s 26-21 win over the 49ers in Santa Clara, Calif.

Saleh was restrained by a 49ers staff member, and Coen by Jaguars offensive lineman Robert Hainsey, according to multiple reports of the midfield encounter when coaches and players from both teams more typically exchange pleasantries and congratulations.

“Not a big deal,” Coen, a first-year head coach whose team is 3-1, told reporters after the game. “I’m just going to keep that between us right now. That’s it.”

Saleh, a former New York Jets head coach and longtime NFL assistant, was not available to the media after the game.

49ers DC Robert Saleh, Jags coach Liam Coen in heated exchange after game

Upcoming San Francisco 49ers Schedule

• Thursday, October 2nd – @ Los Angeles Rams – 5:15 PM PT
• Sunday, October 12th – @ Tampa Bay Buccaneers – 10:00 AM PT
• Sunday, October 19th – vs. Atlanta Falcons – 5:20 PM PT
• Sunday, October 26th – @ Houston Texans – 10:00 AM PT
• Sunday, November 2nd – @ New York Giants – 10:00 AM PT

Thank you for reading sactownsports.com. Follow us on Twitter and Google News, and subscribe to our YouTube channel.

Related

Entering 2026, health remains the 49ers’ greatest concernTrent Williams Ranked No. 40 in NFL Top 100Kyle Shanahan provides key 49ers injury updates ahead of preseason finaleFaithful Flashbacks #11: The Catch IIBrooks: De’Zhaun Stribling is “the absolute real deal”Christian McCaffrey could see a lighter workload in 2026