49ers QB Brock Purdy (toe) ruled out vs. Rams

San Francisco 49ers quarterback Brock Purdy will miss Thursday night’s showdown against the host Los Angeles Rams due to his turf toe injury.

Purdy missed practice on Wednesday for the third straight day.

This will mark Purdy’s third absence in four games due to the injury. He was initially hurt during a Week 1 contest against the Seattle Seahawks and aggravated the injury during last week’s 26-21 home loss against the Jacksonville Jaguars.

49ers QB Brock Purdy (toe) ruled out for TNF at Rams. pic.twitter.com/sTbwDOVl3z

— NFL (@NFL) October 1, 2025

More on Brock Purdy & the 49ers

Mac Jones will draw the start for the 49ers (3-1). He started in Weeks 2 and 3 when Purdy was sidelined. Jones injured a knee during Week 3 but is now healthy and was a full practice participant all week.

Receivers Jauan Jennings (ankle/rib), Ricky Pearsall (knee) and Jordan Watkins (calf) and defensive end Robert Beal Jr. (ankle) also were declared out after not practicing this week.

Defensive lineman CJ West (thumb) is questionable. He was a limited participant on Wednesday.

Purdy, 25, has completed 48 of 73 passes for 586 yards, with four touchdowns and four interceptions in his two games as a starter. Jones, 27, is 53-of-80 passing for 563 yards, with four scores and one pick while going 2-0 in his two starts.

San Francisco will be shorthanded in terms of receiving targets as star tight end George Kittle (hamstring) is on injured reserve and standout receiver Brandon Aiyuk (knee) is still recovering from a serious knee injury sustained nearly 12 months ago.

–Field Level Media

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San Francisco 49ers defensive coordinator Robert Saleh blamed his own word choice for sparking a postgame tiff with Jacksonville Jaguars coach Liam Coen after the teams’ Sunday game.

Days before the contest, Saleh discussed Coen and the Jaguars being adept at “legal signal stealing.”

Jacksonville went on to beat San Francisco 26-21. As the teams met at midfield postgame, Coen sought out Saleh. Video from Action Sports Jax showed Coen saying, “Keep my name out of your mouth. Keep my name out of your f–ing mouth.” Saleh responded, “I will f– your world up.”

Saleh took a much different tone on Tuesday.

“It is all good,” the former New York Jets head coach said. “Whatever happened on Sunday doesn’t change how I feel. In my heart, I genuinely was trying to give a compliment, and I own the fact that I probably used the wrong choice of words, but however you want to word it. …

“Obviously, I did a poor job with the words. I mean, if I said the words ‘film study,’ I don’t think we’re really talking about this. But I used ‘signal stealing’ and that’s why I was so adamant about ‘legally.’ I was just struggling for the words, but for Sean (McVay, the Los Angeles Rams’ head coach), same thing. These guys are the best in the world and that’s why they’re there.”

49ers DC Robert Saleh clarifies remarks about Jags coach Liam Coen

Upcoming San Francisco 49ers Schedule

• Thursday, October 2nd – @ Los Angeles Rams – 5:15 PM PT
• Sunday, October 12th – @ Tampa Bay Buccaneers – 10:00 AM PT
• Sunday, October 19th – vs. Atlanta Falcons – 5:20 PM PT
• Sunday, October 26th – @ Houston Texans – 10:00 AM PT
• Sunday, November 2nd – @ New York Giants – 10:00 AM PT

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